ribogenesis

Dear Editor, Nucleophosmin (NPM1) is a nucleolar protein implicated in ribogenesis, centrosome duplication and stress response. 1 NPM1 is mutated in ~30% of acute myeloid leukemia (AML) patients. 2 Heterozygous mutations involve few base duplications or insertions in the gene's last exon.

2014 September 25, A De Cola et al., “AML cells carrying NPM1 mutation are resistant to nucleophosmin displacement from nucleoli caused by the G-quadruplex ligand TmPyP4”, in Cell Death & Disease, volume 5, →DOI