topoisomerase

T1O1P3O1I1S1O1M3E1R1A1S1E1
UK/ˌtɒpəʊˌaɪˈsɒməˌɹeɪs/US/ˌtɑpoʊˌaɪˈsɑməˌɹeɪs/

noun

Any of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.

UncommonScrabble 17

Meanings

nountopoisomerase (plural topoisomerases)

plural topoisomerases

  1. biochemistryAny of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.

    Synonyms: isotopomerase

Synonyms & antonyms

nounAny of several enzymes that affect the topology of DNA, especially ones that relax supercoiling.

Origin

  1. Ancient Greekτόπος (tópos)
  2. Englishtopo-
  3. Englishisomer
  4. Proto-Indo-European*dwóh₁
  5. Proto-Indo-European*trísinflu.
  6. Proto-Indo-European*dwís
  7. Ancient Greekδιά (diá)
  8. Ancient Greekδῐᾰ- (dĭă-)
  9. Proto-Indo-European*steh₂-
  10. Proto-Indo-European*stísteh₂ti
  11. Proto-Hellenic*hístāmi
  12. Ancient Greekῐ̔́στημῐ (hĭ́stēmĭ)
  13. Ancient Greekδῐῐ̈́στημῐ (dĭĭ̈́stēmĭ)
  14. Ancient Greekδῐᾰ́στᾰσῐς (dĭắstăsĭs)
  15. Englishdiastase
  16. Englishisomerase
  17. Englishtopoisomerase

From topo- + isomerase.

Full word history & related roots →

Translations

Chinese Mandarin 拓扑异构酶
  • 拓扑异构酶 (tuòpū yìgòuméi)enzymes that affect the topology of DNA
Finnish topoisomeraasi
  • topoisomeraasienzymes that affect the topology of DNA

Rhymes & wordplay

Anagrams

Cite this entry
APA

topoisomerase. (n.d.). In WatkinsX Dictionary. Retrieved November 4, 2026, from https://dictionary.watkinsx.com/word/topoisomerase

MLA

“topoisomerase.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/topoisomerase. Accessed November 4, 2026.

Chicago

WatkinsX Dictionary, s.v. “topoisomerase,” accessed November 4, 2026, https://dictionary.watkinsx.com/word/topoisomerase.

Source: topoisomerase on Wiktionary, CC BY-SA 4.0.