underinduced

Because the overinduced vulval phenotype caused by loss of lin-1 activity is the opposite of the underinduced phenotype resulting from reduction of Wnt pathway activity ( Eisenmann et al. 1998 ; Eisenmann and Kim 2000 ; Gleason et al. 2006 ), it was intriguing to identify lin-1 as a possible Wnt pathway target. qPCR showed that endogenous lin-1 transcript levels increased slightly upon Wnt pathway activation and decreased slightly upon Wnt pathway inhibition ( Table S5 ).

2015 June 5, Lakshmi Gorrepati et al., “Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans”, in G3: Genes, volume 5, →DOI