Meanings
proper noun
- The antidepressant medicine sertraline.
And I might need Zoloft, but for now, these Xannies'll do / Hear the sound, a manic depressive
2018, “OSOM”, in Redemption, performed by Jay Rock ft. J. ColeSynonyms: Lustral
Synonyms & antonyms
proper nounThe antidepressant medicine sertraline.
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More synonyms by meaning
nouna selective-serotonin reuptake inhibitor commonly prescribed as an antidepressant (trade name Zoloft)
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Broader
selective-serotonin reuptake inhibitorSSRI
Also see
Synonym sets from Open English WordNet, CC BY 4.0.
Origin
A marketing coinage.
Full word history & related roots →Cite this entry
APA
Zoloft. (n.d.). In WatkinsX Dictionary. Retrieved November 2, 2026, from https://dictionary.watkinsx.com/word/Zoloft
MLA
“Zoloft.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/Zoloft. Accessed November 2, 2026.
Chicago
WatkinsX Dictionary, s.v. “Zoloft,” accessed November 2, 2026, https://dictionary.watkinsx.com/word/Zoloft.
Source: Zoloft on Wiktionary, CC BY-SA 4.0.