antagonistic

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UK/ænˌtæɡ.əˈnɪs.tɪk/Canada, US[ɛənˌtæɡ.əˈnɪs.tɪk]

adjective

Contending or acting against.

Less commonScrabble 15

Meanings

adjectiveantagonistic (comparative more antagonistic, superlative most antagonistic)

comparative more antagonistic · superlative most antagonistic

  1. Contending or acting against.

    They were distinct, adverse, even antagonistic.

    1855, Henry Hart Milman, History of Latin Christianity
    3 more examples

    Though the tephrosia is a powerful agent, and, if carried too far beyond the antagonistic action of the poison, is, I presume, not entirely without danger, I have never known any bad symptoms to arise from its use.

    1866, American Journal of Pharmacy and the Sciences Supporting Public Health

    And deputies from opposing parties, inherently more antagonistic than deputies from the same party, can be bought at a lower price.

    2002, Barry Ames, The Deadlock of Democracy in Brazil, page 171

    The tone of congressional hearings involving tech industry executives in recent years can best be described as antagonistic.

    2023 May 16, Cecilia Kang, “OpenAI’s Sam Altman Urges A.I. Regulation in Senate Hearing”, in The New York Times, →ISSN

    Synonyms: hostile, adverse, aggressive, assaultive, bellicose, belligerent, combative, martial

  2. biochemistryRelating to an antagonist.

Synonyms & antonyms

More synonyms by meaning

adjectiveindicating opposition or resistance

adjectivecharacterized by antagonism or antipathy

adjectivearousing animosity or hostility

Similar
Opposite

adjectiveused especially of drugs or muscles that counteract or neutralize each other's effect

Opposite

adjectiveincapable of harmonious association

Synonym sets from Open English WordNet, CC BY 4.0.

Origin

Translations

Catalan antagonista
  • antagonistacontending
Chinese Mandarin 對抗性的 /对抗性的
  • 對抗性的 /对抗性的 (duìkàngxìng de)contending
Esperanto antagonista
  • antagonistacontending
French antagonique
  • antagoniquecontending
German antagonistisch
  • antagonistischcontending
Greek ανταγωνιστικός
  • ανταγωνιστικός (antagonistikós)contending
Hungarian antagonisztikus, ellenséges
  • antagonisztikuscontending
  • ellenségescontending
  • szemben állócontending
  • antagonistabiochemistry: relating to an antagonist
Latin infestus
  • infestuscontending
Māori nihoniho, ngākaukino
  • nihonihocontending
  • ngākaukinocontending
Polish antagonistyczny
  • antagonistycznycontending
Portuguese antagonista, antagónico
  • antagonistacontending
  • antagónicocontending
  • antagônicocontending
  • antagonísticocontending
Romanian antagonic, antagonist
  • antagoniccontending
  • antagonistcontending
Spanish antagonista, antagónico
  • antagonistacontending
  • antagónicocontending
Cite this entry
APA

antagonistic. (n.d.). In WatkinsX Dictionary. Retrieved November 3, 2026, from https://dictionary.watkinsx.com/word/antagonistic

MLA

“antagonistic.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/antagonistic. Accessed November 3, 2026.

Chicago

WatkinsX Dictionary, s.v. “antagonistic,” accessed November 3, 2026, https://dictionary.watkinsx.com/word/antagonistic.

Source: antagonistic on Wiktionary, CC BY-SA 4.0.