citrullinate

present singular third person citrullinates · participle present citrullinating · participle past citrullinated · past citrullinated

1. transitivebiochemistryTo react with, or convert to, citrulline.

   It has been shown that PPAD is able to citrullinate bacterial as well as host peptides such as fibrinogen and α-enolase.

   2015 August 29, Stefan Reichert et al., “Association of levels of antibodies against citrullinated cyclic peptides and citrullinated α-enolase in chronic and aggressive periodontitis as a risk factor of Rheumatoid arthritis: a case control study”, in Journal of Translational Medicine, volume 13, →DOI

   2 more examples

   PADs do not typically citrullinate total arginines found in the amino acid sequence of a protein, but certain arginines are more susceptible to citrullination.[…]Likewise, PAD2 also citrullinates actin and myelin basic protein in the CNS, while PAD4 can citrullinate substrates like nucleophosmin, nuclear lamin C, and p21 (Lamensa and Moscarello 1993; Hagiwara et al. 2002; Tanikawa et al. 2012; Li et al. 2008).

   2017, E. E. Witalison, L. J. Hofseth, “22: Citrullination in Inflammatory-Driven Carcinogenesis of the Colon”, in Anthony P. Nicholas, Sanjoy K. Bhattacharya, Paul R. Thompson, editors, Protein Deimination in Human Health and Disease, 2nd edition, Springer, page 433

   Furthermore, PPAD in contrast to human PAD is capable of citrullinating C-terminal arginine residues, which are generated by another Pg.-derived enzyme, arginine specific gingipain (Rgp) protease (81).

   2020, Burkhard Möller, Florian Kollert, Anton Sculean, Peter M. Villiger, “79: Infectious Trigger in Periodontitis and the Gut in Rheumatoid Arthritis (RA)”, in Erminia Mariani, Mariagrazia Uguccioni, Daniela Frasca, editors, Immunobiology of Osteoarticular Diseases, Frontiers Media, page 83