Meanings
- uncountablechemistryAn antibiotic produced by the bacterium Burkholderia gladioli, with potential applications in treating tuberculosis.
Gladiolin is structurally related to etnangien, a highly unstable antibiotic from Sorangium cellulosum that is also active against Mycobacteria.
2017, Lijiang Song et al., “Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis”, in Journal of the American Chemical Society, →DOI, page 79742 more examples
The configuration of all but one of the stereogenic centers of gladiolin has previously been elucidated using a combination of NOESY NMR experiments and predictive sequence analysis of the polyketide synthase responsible for its assembly.
2018, Christopher Perry, Jacob R. Sargeant, Lijiang Song, Gregory L. Challis, “Relative stereochemical assignment of C-33 and C-35 in the antibiotic gladiolin”, in Tetrahedron, →DOI, page 5150In this study, a previously uncharacterised trans-AT PKS subunit interface between a ketoreductase and a methyltransferase domain (KR/MT junction) is examined from the gladiolin trans-AT PKS.
2020, Helen Smith, Lona Alkhalaf, Józef Lewandowski, Greg Challis, Matthew Jenner, “Reconstitution of a split C-methylating module from the gladiolin trans-AT polyketide synthase”, in 3rd International Conference on Natural Products Discovery and Development in the Genomic Era
Origin
Cite this entry
gladiolin. (n.d.). In WatkinsX Dictionary. Retrieved November 3, 2026, from https://dictionary.watkinsx.com/word/gladiolin
“gladiolin.” WatkinsX Dictionary, https://dictionary.watkinsx.com/word/gladiolin. Accessed November 3, 2026.
WatkinsX Dictionary, s.v. “gladiolin,” accessed November 3, 2026, https://dictionary.watkinsx.com/word/gladiolin.
Source: gladiolin on Wiktionary, CC BY-SA 4.0.